Calcium acts as cofactor for activation of plasma enriched with human growth factors which allows turning fibrin plasma into fibrin, forming gel or clot with important biological functions. On the one side, fibrin is excellent matrix for cells keeping and placement, it acts as temporary carcass for certain tissue regeneration, as well as permanently acting system of growth factors secretion.
Thus, fibrin is a biocompatible and autogenous sponge filled with growth factors and cytokines which allows their progressing release during several weeks.
Fibrin derived from plasma rich in growth factors is probably the best biomaterial for stimulating tissue regeneration.
Biological mediators in plasma enriched with human growth factors stimulate and support such important processes as cells proliferation and migration, chemotaxis (or signal to distant cells to get into lesion site), inflammation and auto/paracrine synthesis of new biologically active molecules.